Itraconazole and Rivaroxaban Interaction
Drug interaction information between Itraconazole and Rivaroxaban.
Itraconazole and Rivaroxaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Itraconazole and Rivaroxaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole interferes with how your body processes rivaroxaban, which increases the risk of having too much drug in your blood.
FDA Label Information
Apixaban Rivaroxaban Vorapaxar Not recommended during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Ketoconazole moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Rivaroxaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Rivaroxaban's 14. In the moderate band specifically: Itraconazole has 20 (also Tamsulosin, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir, Aliskiren); Rivaroxaban has 13 (also Clopidogrel, Aspirin, Warfarin, Ketoconazole).
What mechanism field is on file for Itraconazole and Rivaroxaban?
Itraconazole interferes with how your body processes rivaroxaban, which increases the risk of having too much drug in your blood.
Itraconazole carries more major-labeled pairs than Rivaroxaban
SPL source-record counts only. This page's band is moderate · classes on file: Itraconazole (Azole Antifungal); Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Itraconazole has 19 major-labeled pairs vs Rivaroxaban's 0. This page itself is in the moderate band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
- Aliskiren
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Clopidogrel
- Aspirin
- Warfarin
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.