What the FDA labels say about taking them together
Itraconazole and rivaroxaban
Itraconazole's FDA label of July 13, 2026 names rivaroxaban in its drug interactions section; the rivaroxaban labels PlainMeds reads (2) do not name itraconazole. The itraconazole label: “Apixaban Rivaroxaban Vorapaxar Not recommended during and 2 weeks after TOLSURA treatment. Cilostazol Dabigatran Warfarin Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the rivaroxaban FDA label on DailyMed (effective September 10, 2026, Janssen Pharmaceuticals, Inc.).
What does the itraconazole label say about rivaroxaban?
Itraconazole label, drug interactionsApixaban Rivaroxaban Vorapaxar Not recommended during and 2 weeks after SPORANOX ® treatment. Cilostazol Dabigatran Warfarin Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the rivaroxaban label say about itraconazole?
Rivaroxaban's label (effective September 10, 2026) and its 1 other brand-application label do not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xarelto), Janssen Pharmaceuticals, Inc., effective September 10, 2026 (SPL set 10db92f9-2300-4a80-836b-673e1ae91610), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Rivaroxaban | |
|---|---|---|
| Labeled for | Fungal infections | Atrial fibrillation, Heart attack and coronary artery disease, Blood clots (DVT and PE), Stroke prevention |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.650 per tablet 2.5 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once