Itraconazole and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Itraconazole and Glecaprevir/Pibrentasvir.
Itraconazole and Glecaprevir/Pibrentasvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Itraconazole and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the body's ability to break down these hepatitis C medicines. This can cause the drugs to build up to high levels in your blood.
FDA Label Information
Elbasvir/grazoprevir Glecaprevir/pibrentasvir Tenofovir disoproxil fumarate Not recommended during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Glecaprevir/Pibrentasvir's 38. In the moderate band specifically: Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Aliskiren); Glecaprevir/Pibrentasvir has 9 (also Cyclosporine, Darunavir, Estradiol, Ethinyl Estradiol).
What mechanism field is on file for Itraconazole and Glecaprevir/Pibrentasvir?
Itraconazole blocks the body's ability to break down these hepatitis C medicines. This can cause the drugs to build up to high levels in your blood.
Itraconazole carries more major-labeled pairs than Glecaprevir/Pibrentasvir
SPL source-record counts only. This page's band is moderate · classes on file: Itraconazole (Azole Antifungal); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Itraconazole has 19 major-labeled pairs vs Glecaprevir/Pibrentasvir's 3. This page itself is in the moderate band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Aliskiren
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Cyclosporine
- Darunavir
- Estradiol
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.