trandolapril vs warfarin
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Side-by-side comparison of trandolapril and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
The anticoagulant effect of warfarin was not significantly changed by trandolapril.
Mavik
Coumadin, Jantoven
Trandolapril (Mavik) is a medicine that lowers blood pressure. It can also help people who have had a heart attack and have a weak heart.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
Trandolapril is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. It is also used in people who have had a heart attack and have a weak heart (left ventricular dysfunction) or heart failure.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Trandolapril belongs to a class of drugs called ACE inhibitors. It works by blocking a substance in your body that tightens blood vessels. This helps your blood vessels relax and lowers your blood pressure.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Cough
- • Dizziness
- • Bleeding from any tissue or organ
- Dyspnoea 137
- Fatigue 119
- Dizziness 108
- Diarrhoea 99
- Cough 97
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
If you become pregnant, stop taking trandolapril right away. This medicine can harm or cause death to your unborn baby.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
Do not take trandolapril if you are pregnant. It can cause serious harm to your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This trandolapril vs warfarin Comparison
trandolapril is classified in the ACE Inhibitor drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, trandolapril has 560 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to trandolapril does not change how well warfarin works to thin your blood. the two drugs do not have a meaningful interaction.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for trandolapril or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.