Tiagabine and Digoxin Interaction
Drug interaction information between Tiagabine and Digoxin.
Tiagabine and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tiagabine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not interfere with each other's levels or how the body uses them.
FDA Label Information
Digoxin: Concomitant administration of tiagabine did not affect the steady-state pharmacokinetics of digoxin or the mean daily trough serum level of digoxin.
Tiagabine Also Interacts With
- Gabapentin minor
- Warfarin minor
- Valproate minor
- Theophylline minor
- Cimetidine minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Tiagabine + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Tiagabine's 11. In the minor band specifically: Tiagabine has 11 (also Gabapentin, Warfarin, Valproate, Theophylline); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Tiagabine and Digoxin?
These two drugs do not interfere with each other's levels or how the body uses them.
Digoxin carries more major-labeled pairs than Tiagabine
SPL source-record counts only. This page's band is minor · classes on file: Tiagabine (Anticonvulsant (GABA Reuptake Inhibitor)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Tiagabine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Tiagabine
- Gabapentin
- Warfarin
- Valproate
- Theophylline
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.