Tiagabine and Cimetidine Interaction
Drug interaction information between Tiagabine and Cimetidine.
Tiagabine and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tiagabine and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine does not affect the way the body processes or removes tiagabine.
FDA Label Information
Interaction of Tiagabine Hydrochloride with Other Drugs: Cimetidine: Co-administration of cimetidine (800 mg/day) to patients taking tiagabine chronically had no effect on tiagabine pharmacokinetics.
Tiagabine Also Interacts With
- Gabapentin minor
- Warfarin minor
- Valproate minor
- Digoxin minor
- Theophylline minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Tiagabine + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Tiagabine's 11. In the minor band specifically: Tiagabine has 11 (also Gabapentin, Warfarin, Valproate, Digoxin); Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Alprazolam).
What mechanism field is on file for Tiagabine and Cimetidine?
Cimetidine does not affect the way the body processes or removes tiagabine.
Cimetidine carries more major-labeled pairs than Tiagabine
SPL source-record counts only. This page's band is minor · classes on file: Tiagabine (Anticonvulsant (GABA Reuptake Inhibitor)); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Tiagabine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Tiagabine
- Gabapentin
- Warfarin
- Valproate
- Digoxin
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Alprazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.