digoxin vs tiagabine
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Side-by-side comparison of digoxin and tiagabine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Digoxin: Concomitant administration of tiagabine did not affect the steady-state pharmacokinetics of digoxin or the mean daily trough serum level of digoxin.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Tiagabine is a medicine used with other medicines to treat partial seizures. It helps to control seizures by affecting certain chemicals in the brain.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Tiagabine is used to treat partial seizures in adults and children 12 years and older. It is used along with other seizure medicines. Partial seizures affect only one part of the brain.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Tiagabine works by increasing the amount of a chemical called GABA in the brain. GABA helps to calm the brain and reduce seizures. Tiagabine blocks the reuptake of GABA, which means more GABA is available in the brain.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Dizziness
- • Lack of energy
- • Sleepiness
- • Nausea
- • Nervousness or irritability
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Encephalopathy 16
- Myoclonus 14
- Dizziness 6
- Feeling Abnormal 5
- Seizure 5
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
This medicine may cause serious side effects. Tell your doctor right away if you have any changes in mood or behavior, or any suicidal thoughts.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if tiagabine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking tiagabine during pregnancy.
How to Read This digoxin vs tiagabine Comparison
digoxin is classified in the Cardiac Glycoside drug class, while tiagabine sits within the Anticonvulsant (GABA Reuptake Inhibitor) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while tiagabine has 46. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs do not interfere with each other's levels or how the body uses them.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or tiagabine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.