Tiagabine and Gabapentin Interaction
Drug interaction information between Tiagabine and Gabapentin.
Tiagabine and Gabapentin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tiagabine and Gabapentin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gabapentin does not speed up or slow down the liver enzymes that process tiagabine. This means it is unlikely to change how much tiagabine stays in your body.
FDA Label Information
Carbamazepine, phenytoin, primidone, and phenobarbital are generally classified as enzyme inducers; valproate and gabapentin are not.
Tiagabine Also Interacts With
- Warfarin minor
- Valproate minor
- Digoxin minor
- Theophylline minor
- Cimetidine minor
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
Frequently Asked Questions
What SPL severity band is on file for Tiagabine + Gabapentin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gabapentin has 19 labeled pairs on file vs Tiagabine's 11. In the minor band specifically: Tiagabine has 11 (also Warfarin, Valproate, Digoxin, Theophylline); Gabapentin has 18 (also Oxycodone, Estradiol, Naproxen, Norethindrone).
What mechanism field is on file for Tiagabine and Gabapentin?
Gabapentin does not speed up or slow down the liver enzymes that process tiagabine. This means it is unlikely to change how much tiagabine stays in your body.
Gabapentin's labeled portfolio outnumbers Tiagabine
SPL source-record counts only. This page's band is minor · classes on file: Tiagabine (Anticonvulsant (GABA Reuptake Inhibitor)); Gabapentin (Anticonvulsant / Nerve Pain Agent).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Tiagabine
- Warfarin
- Valproate
- Digoxin
- Theophylline
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Naproxen
- Norethindrone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.