Tenofovir Disoproxil and Ledipasvir/Sofosbuvir Interaction
Drug interaction information between Tenofovir Disoproxil and Ledipasvir/Sofosbuvir.
Tenofovir Disoproxil and Ledipasvir/Sofosbuvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tenofovir Disoproxil and Ledipasvir/Sofosbuvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can increase the amount of tenofovir in your blood.
FDA Label Information
Hepatitis C Antiviral Agents: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/ voxilaprevir ledipasvir/sofosbuvir ↑ tenofovir Monitor patients receiving tenofovir disoproxil fumarate tablets concomitantly with EPCLUSA ® (sofosbuvir/velpatasvir) or VOSEVI ® (sofosbuvir/velpatasvir/voxilaprevir) for adverse reactions associated with tenofovir DF. Monitor patients receiving tenofovir disoproxil fumarate tablets concomitantly with HARVONI ® (ledipasvir/sofosbuvir) without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination for adverse reactions associated...
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Darunavir minor
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
Frequently Asked Questions
What SPL severity band is on file for Tenofovir Disoproxil + Ledipasvir/Sofosbuvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Tenofovir Disoproxil's 14. In the minor band specifically: Tenofovir Disoproxil has 13 (also Valacyclovir, Acyclovir, Gentamicin, Darunavir); Ledipasvir/Sofosbuvir has 17 (also Omeprazole, Pravastatin, Warfarin, Verapamil).
What mechanism field is on file for Tenofovir Disoproxil and Ledipasvir/Sofosbuvir?
Taking these drugs together can increase the amount of tenofovir in your blood.
Ledipasvir/Sofosbuvir's labeled portfolio outnumbers Tenofovir Disoproxil
SPL source-record counts only. This page's band is minor · classes on file: Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor); Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)).
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Valacyclovir
- Acyclovir
- Gentamicin
- Darunavir
0 major · 5 moderate · 17 minor · 22 total
- Other minor peers for Ledipasvir/Sofosbuvir
- Omeprazole
- Pravastatin
- Warfarin
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.