Tenofovir Disoproxil and Darunavir Interaction
Drug interaction information between Tenofovir Disoproxil and Darunavir.
Tenofovir Disoproxil and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tenofovir Disoproxil and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir can cause the levels of tenofovir in your blood to go up, which makes side effects from tenofovir more likely.
FDA Label Information
HIV-1 Protease Inhibitors : atazanavir lopinavir/ritonavir atazanavir/ritonavir darunavir/ritonavir ↓ atazanavir ↑ tenofovir When coadministered with tenofovir disoproxil fumarate tablets, atazanavir 300 mg should be given with ritonavir 100 mg. Monitor patients receiving tenofovir disoproxil fumarate tablets concomitantly with lopinavir/ritonavir, ritonavir-boosted atazanavir, or ritonavir-boosted darunavir for tenofovir DF-associated adverse reactions.
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Ledipasvir/Sofosbuvir minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Tenofovir Disoproxil + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Tenofovir Disoproxil's 14. In the minor band specifically: Tenofovir Disoproxil has 13 (also Valacyclovir, Acyclovir, Gentamicin, Ledipasvir/Sofosbuvir); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Tenofovir Disoproxil and Darunavir?
Darunavir can cause the levels of tenofovir in your blood to go up, which makes side effects from tenofovir more likely.
Darunavir carries more major-labeled pairs than Tenofovir Disoproxil
SPL source-record counts only. This page's band is minor · classes on file: Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Tenofovir Disoproxil's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Valacyclovir
- Acyclovir
- Gentamicin
- Ledipasvir/Sofosbuvir
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.