Tenofovir Disoproxil and Gentamicin Interaction
Drug interaction information between Tenofovir Disoproxil and Gentamicin.
Tenofovir Disoproxil and Gentamicin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tenofovir Disoproxil and Gentamicin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can be hard on the kidneys, and taking them at the same time increases the risk of kidney damage.
FDA Label Information
Some examples include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions ( 5.2)].
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Valacyclovir minor
- Acyclovir minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Gentamicin Also Interacts With
- Cidofovir major
- Bictegravir/Emtricitabine/Tenofovir minor
- Digoxin minor
- Emtricitabine/Tenofovir minor
- Perindopril minor
Frequently Asked Questions
What SPL severity band is on file for Tenofovir Disoproxil + Gentamicin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tenofovir Disoproxil has 14 labeled pairs on file vs Gentamicin's 7. In the minor band specifically: Tenofovir Disoproxil has 13 (also Valacyclovir, Acyclovir, Darunavir, Ledipasvir/Sofosbuvir); Gentamicin has 6 (also Bictegravir, Digoxin, Emtricitabine/Tenofovir, Perindopril).
What mechanism field is on file for Tenofovir Disoproxil and Gentamicin?
Both of these medications can be hard on the kidneys, and taking them at the same time increases the risk of kidney damage.
Gentamicin carries more major-labeled pairs than Tenofovir Disoproxil
SPL source-record counts only. This page's band is minor · classes on file: Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor); Gentamicin (Aminoglycoside Antibiotic).
Gentamicin has 1 major-labeled pair vs Tenofovir Disoproxil's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Valacyclovir
- Acyclovir
- Darunavir
- Ledipasvir/Sofosbuvir
1 major · 0 moderate · 6 minor · 7 total
- Other minor peers for Gentamicin
- Bictegravir
- Digoxin
- Emtricitabine/Tenofovir
- Perindopril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.