ledipasvir/sofosbuvir vs tenofovir disoproxil
Side-by-side comparison of ledipasvir/sofosbuvir and tenofovir disoproxil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Hepatitis C Antiviral Agents: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/ voxilaprevir ledipasvir/sofosbuvir ↑ tenofovir Monitor patients receiving tenofovir disoproxil fumarate tablets concomitantly with EPCLUSA ® (sofosbuvir/velpatasvir) or VOSEVI ® (sofosbuvir/velpatasvir/voxilaprevir) for adverse reactions associated with tenofovir DF. Monitor patients receiving tenofovir disoproxil fumarate tablets concomitantly with HARVONI ® (ledipasvir/sofosbuvir) without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination for adverse reactions associated...
Recommendation: Your doctor should monitor you closely for any side effects caused by tenofovir while you are taking both medications.
Harvoni
Viread
Harvoni is a medicine that contains ledipasvir and sofosbuvir. It is used to treat chronic hepatitis C virus (HCV) infection in adults and children 3 years and older.
Tenofovir disoproxil fumarate is a medicine used to treat HIV and hepatitis B. It helps to lower the amount of virus in your body.
Harvoni treats chronic Hepatitis C virus (HCV) genotypes 1, 4, 5, or 6. It can be used if you don't have cirrhosis or if you have compensated cirrhosis. If you have genotype 1 with decompensated cirrhosis or are a liver transplant recipient with genotype 1 or 4, you will take Harvoni with another medicine called ribavirin.
This medicine treats HIV-1 in adults and children at least 2 years old. It is always used with other HIV medicines. It also treats chronic hepatitis B in adults and children at least 12 years old.
Harvoni contains two medicines that stop the hepatitis C virus from multiplying in your body. Ledipasvir blocks a protein called NS5A. Sofosbuvir blocks another protein called NS5B.
Tenofovir disoproxil fumarate blocks an enzyme that HIV and hepatitis B need to multiply. This lowers the amount of virus in your body. It can help your immune system get stronger.
- • Feeling tired
- • Headache
- • Feeling weak
- • Nausea
- • Rash
- • Diarrhea
- • Headache
- • Pain
- • Depression
- Feeling tired 4,130
- Headache 3,706
- Nausea 1,240
- Diarrhea 913
- Hepatitis C 883
- Bone Density Decreased 10,625
- Renal Injury 9,276
- Skeletal Injury 8,327
- Chronic Kidney Disease 7,247
- Osteonecrosis 7,245
Harvoni can cause Hepatitis B to become active again if you have had it in the past. This can cause serious liver problems, including liver failure and death. Your doctor will test you for Hepatitis B before you start Harvoni and monitor you during and after treatment.
After stopping this medicine, hepatitis B may get worse. Your doctor will monitor your liver closely for several months after you stop taking it. If needed, you may have to restart hepatitis B treatment.
If you are pregnant or plan to become pregnant, talk to your doctor before taking Harvoni. If Harvoni is taken with ribavirin, it is unsafe during pregnancy. Talk to your doctor if you are breastfeeding or plan to breastfeed.
Tell your doctor if you are pregnant or plan to become pregnant. HIV-infected mothers should not breastfeed because of the risk of passing HIV to the baby.
How to Read This ledipasvir/sofosbuvir vs tenofovir disoproxil Comparison
ledipasvir/sofosbuvir is classified in the NS5A/NS5B Inhibitor (HCV) drug class, while tenofovir disoproxil sits within the Nucleotide Reverse Transcriptase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ledipasvir/sofosbuvir has 10,872 submissions while tenofovir disoproxil has 42,720. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking these drugs together can increase the amount of tenofovir in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between ledipasvir/sofosbuvir and tenofovir disoproxil - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.