Tenofovir Disoproxil and Acyclovir Interaction
Drug interaction information between Tenofovir Disoproxil and Acyclovir.
Tenofovir Disoproxil and Acyclovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tenofovir Disoproxil and Acyclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs are both filtered out of the body by the kidneys, which can increase the risk of kidney strain when used at the same time.
FDA Label Information
Some examples include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions ( 5.2)].
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Valacyclovir minor
- Gentamicin minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Acyclovir Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir minor
- Cidofovir minor
- Emtricitabine/Tenofovir minor
- Meperidine minor
- Tizanidine minor
Frequently Asked Questions
What SPL severity band is on file for Tenofovir Disoproxil + Acyclovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tenofovir Disoproxil has 14 labeled pairs on file vs Acyclovir's 7. In the minor band specifically: Tenofovir Disoproxil has 13 (also Valacyclovir, Gentamicin, Darunavir, Ledipasvir/Sofosbuvir); Acyclovir has 7 (also Bictegravir, Cidofovir, Emtricitabine/Tenofovir, Meperidine).
What mechanism field is on file for Tenofovir Disoproxil and Acyclovir?
These two drugs are both filtered out of the body by the kidneys, which can increase the risk of kidney strain when used at the same time.
Tenofovir Disoproxil's labeled portfolio outnumbers Acyclovir
SPL source-record counts only. This page's band is minor · classes on file: Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor); Acyclovir (Antiviral (Nucleoside Analog)).
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Valacyclovir
- Gentamicin
- Darunavir
- Ledipasvir/Sofosbuvir
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Acyclovir
- Bictegravir
- Cidofovir
- Emtricitabine/Tenofovir
- Meperidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.