Tenofovir Disoproxil and Itraconazole Interaction
Drug interaction information between Tenofovir Disoproxil and Itraconazole.
Tenofovir Disoproxil and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tenofovir Disoproxil and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole can cause tenofovir levels to increase by changing how the body handles the drug.
FDA Label Information
Elbasvir/grazoprevir Glecaprevir/pibrentasvir Tenofovir disoproxil fumarate Not recommended during and 2 weeks after itraconazole treatment.
Tenofovir Disoproxil Also Interacts With
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Tenofovir Disoproxil + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Tenofovir Disoproxil's 14. In the moderate band specifically: Tenofovir Disoproxil has 1; Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Glecaprevir/Pibrentasvir, Aliskiren).
What mechanism field is on file for Tenofovir Disoproxil and Itraconazole?
Itraconazole can cause tenofovir levels to increase by changing how the body handles the drug.
Itraconazole carries more major-labeled pairs than Tenofovir Disoproxil
SPL source-record counts only. This page's band is moderate · classes on file: Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Tenofovir Disoproxil's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
Tenofovir Disoproxil has no other moderate-band peer in this dataset besides Itraconazole.
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Glecaprevir/Pibrentasvir
- Aliskiren
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.