Tenofovir Disoproxil and Valacyclovir Interaction
Drug interaction information between Tenofovir Disoproxil and Valacyclovir.
Tenofovir Disoproxil and Valacyclovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tenofovir Disoproxil and Valacyclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs are removed from the body by the kidneys, and taking them together can put extra stress on your kidney function.
FDA Label Information
Some examples include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions ( 5.2)].
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Acyclovir minor
- Gentamicin minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Valacyclovir Also Interacts With
View all Valacyclovir interactions →Frequently Asked Questions
What SPL severity band is on file for Tenofovir Disoproxil + Valacyclovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tenofovir Disoproxil has 14 labeled pairs on file vs Valacyclovir's 3. In the minor band specifically: Tenofovir Disoproxil has 13 (also Acyclovir, Gentamicin, Darunavir, Ledipasvir/Sofosbuvir); Valacyclovir has 3 (also Bictegravir, Emtricitabine/Tenofovir).
What mechanism field is on file for Tenofovir Disoproxil and Valacyclovir?
Both of these drugs are removed from the body by the kidneys, and taking them together can put extra stress on your kidney function.
Tenofovir Disoproxil's labeled portfolio outnumbers Valacyclovir
SPL source-record counts only. This page's band is minor · classes on file: Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor); Valacyclovir (Antiviral).
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Acyclovir
- Gentamicin
- Darunavir
- Ledipasvir/Sofosbuvir
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Valacyclovir
- Bictegravir
- Emtricitabine/Tenofovir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.