itraconazole vs tenofovir disoproxil
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Side-by-side comparison of itraconazole and tenofovir disoproxil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Elbasvir/grazoprevir Glecaprevir/pibrentasvir Tenofovir disoproxil fumarate Not recommended during and 2 weeks after itraconazole treatment.
Sporanox
Viread
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Tenofovir disoproxil fumarate is a medicine used to treat HIV and hepatitis B. It helps to lower the amount of virus in your body.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
This medicine treats HIV-1 in adults and children at least 2 years old. It is always used with other HIV medicines. It also treats chronic hepatitis B in adults and children at least 12 years old.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Tenofovir disoproxil fumarate blocks an enzyme that HIV and hepatitis B need to multiply. This lowers the amount of virus in your body. It can help your immune system get stronger.
- • Nausea
- • Rash
- • Headache
- • Rash
- • Diarrhea
- • Headache
- • Pain
- • Depression
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
- Bone Density Decreased 10,625
- Renal Injury 9,276
- Skeletal Injury 8,327
- Chronic Kidney Disease 7,247
- Osteonecrosis 7,245
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
After stopping this medicine, hepatitis B may get worse. Your doctor will monitor your liver closely for several months after you stop taking it. If needed, you may have to restart hepatitis B treatment.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
Tell your doctor if you are pregnant or plan to become pregnant. HIV-infected mothers should not breastfeed because of the risk of passing HIV to the baby.
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How to Read This itraconazole vs tenofovir disoproxil Comparison
itraconazole is classified in the Azole Antifungal drug class, while tenofovir disoproxil sits within the Nucleotide Reverse Transcriptase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,066 submissions while tenofovir disoproxil has 42,720. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to itraconazole can cause tenofovir levels to increase by changing how the body handles the drug.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for itraconazole or tenofovir disoproxil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.