Ciprofloxacin and Carbamazepine Interaction
Drug interaction information between Ciprofloxacin and Carbamazepine.
Ciprofloxacin and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ciprofloxacin and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ciprofloxacin slows down how your body gets rid of carbamazepine, which can cause the drug to build up to high levels.
FDA Label Information
Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors.
Ciprofloxacin Also Interacts With
- Tizanidine major
- Cyclosporine minor
- Theophylline minor
- Clozapine minor
- Duloxetine minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Ciprofloxacin + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Ciprofloxacin's 14. In the minor band specifically: Ciprofloxacin has 13 (also Cyclosporine, Theophylline, Clozapine, Duloxetine); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Ciprofloxacin and Carbamazepine?
Ciprofloxacin slows down how your body gets rid of carbamazepine, which can cause the drug to build up to high levels.
Carbamazepine carries more major-labeled pairs than Ciprofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Ciprofloxacin (Fluoroquinolone Antibiotic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Ciprofloxacin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Cyclosporine
- Theophylline
- Clozapine
- Duloxetine
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.