Ciprofloxacin and Tizanidine Interaction
Drug interaction information between Ciprofloxacin and Tizanidine.
Ciprofloxacin and Tizanidine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ciprofloxacin and Tizanidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ciprofloxacin stops the body from breaking down tizanidine. This can cause tizanidine to build up to dangerous levels in your system.
FDA Label Information
( 7.2 , 12.3 ) 7.1 Strong CYP1A2 Inhibitors Concomitant use of tizanidine with strong cytochrome P450 1A2 (CYP1A2) inhibitors (e.g., fluvoxamine, ciprofloxacin) is contraindicated.
Ciprofloxacin Also Interacts With
- Cyclosporine minor
- Theophylline minor
- Carbamazepine minor
- Clozapine minor
- Duloxetine minor
Tizanidine Also Interacts With
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
- Amiodarone minor
Frequently Asked Questions
What SPL severity band is on file for Ciprofloxacin + Tizanidine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tizanidine has 17 labeled pairs on file vs Ciprofloxacin's 14. In the major band specifically: Ciprofloxacin has 1; Tizanidine has 2 (also Fluvoxamine).
What mechanism field is on file for Ciprofloxacin and Tizanidine?
Ciprofloxacin stops the body from breaking down tizanidine. This can cause tizanidine to build up to dangerous levels in your system.
Tizanidine carries more major-labeled pairs than Ciprofloxacin
SPL source-record counts only. This page's band is major · classes on file: Ciprofloxacin (Fluoroquinolone Antibiotic); Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)).
Tizanidine has 2 major-labeled pairs vs Ciprofloxacin's 1.
1 major · 0 moderate · 13 minor · 14 total
Ciprofloxacin has no other major-band peer in this dataset besides Tizanidine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.