What the FDA labels say about taking them together
Ciprofloxacin and cyclosporine
Ciprofloxacin's FDA label of March 2, 2026 names cyclosporine in its drug interactions section, and cyclosporine's label names ciprofloxacin too. The ciprofloxacin label: “Cyclosporine Use with caution Monitor renal function when CIPRO is co-administered with cyclosporine.”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the ciprofloxacin label say about cyclosporine?
Ciprofloxacin label, drug interactionsCyclosporine Use with caution (transient elevations in serum creatinine) Monitor renal function (in particular serum creatinine) when CIPRO is co-administered with cyclosporine.
Ciloxan label (Sandoz Inc, July 30, 2024), drug interactionsHowever, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Source: FDA drug label (Ciloxan, NDA020369), Sandoz Inc, effective July 30, 2024 (SPL set 09ca5374-2a16-4a95-91b3-70591d78254e), via openFDA
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the cyclosporine label say about ciprofloxacin?
Cyclosporine label, drug interactionsciprofloxacin; melphalan; amphotericin B; azapropazon; cimetidine; tacrolimus; fibric acid derivatives (e.g., bezafibrate, fenofibrate)
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Cyclosporine | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once