Ciprofloxacin and Cyclosporine Interaction
Drug interaction information between Ciprofloxacin and Cyclosporine.
Ciprofloxacin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ciprofloxacin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can cause a temporary increase in creatinine levels, which is a sign of stress on the kidneys.
FDA Label Information
However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Ciprofloxacin Also Interacts With
- Tizanidine major
- Theophylline minor
- Carbamazepine minor
- Clozapine minor
- Duloxetine minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Ciprofloxacin + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Ciprofloxacin's 14. In the minor band specifically: Ciprofloxacin has 13 (also Theophylline, Carbamazepine, Clozapine, Duloxetine); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Ciprofloxacin and Cyclosporine?
Taking these two drugs together can cause a temporary increase in creatinine levels, which is a sign of stress on the kidneys.
Cyclosporine carries more major-labeled pairs than Ciprofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Ciprofloxacin (Fluoroquinolone Antibiotic); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Ciprofloxacin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Theophylline
- Carbamazepine
- Clozapine
- Duloxetine
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.