Ciprofloxacin and Clozapine Interaction
Drug interaction information between Ciprofloxacin and Clozapine.
Ciprofloxacin and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ciprofloxacin and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ciprofloxacin is a strong blocker of the enzyme that clears clozapine, which can cause clozapine levels to become very high.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use of Strong CYP1A2 Inhibitors : Reduce VERSACLOZ dose to one third when coadministered with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, enoxacin) ( 2.7 , 7.1 ). Reduce the VERSACLOZ dose to one third of the original dose when VERSACLOZ is coadministered with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, or enoxacin).
Ciprofloxacin Also Interacts With
- Tizanidine major
- Cyclosporine minor
- Theophylline minor
- Carbamazepine minor
- Duloxetine minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Ciprofloxacin + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Ciprofloxacin's 14. In the minor band specifically: Ciprofloxacin has 13 (also Cyclosporine, Theophylline, Carbamazepine, Duloxetine); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Ciprofloxacin and Clozapine?
Ciprofloxacin is a strong blocker of the enzyme that clears clozapine, which can cause clozapine levels to become very high.
Ciprofloxacin carries more major-labeled pairs than Clozapine
SPL source-record counts only. This page's band is minor · classes on file: Ciprofloxacin (Fluoroquinolone Antibiotic); Clozapine (Atypical Antipsychotic).
Ciprofloxacin has 1 major-labeled pair vs Clozapine's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Cyclosporine
- Theophylline
- Carbamazepine
- Duloxetine
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.