Rosuvastatin/Ezetimibe and Ledipasvir/Sofosbuvir Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Ledipasvir/Sofosbuvir.
Rosuvastatin/Ezetimibe and Ledipasvir/Sofosbuvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin/Ezetimibe and Ledipasvir/Sofosbuvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications can cause rosuvastatin to build up in your system, which increases the risk of harmful side effects.
FDA Label Information
Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Ledipasvir/Sofosbuvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the moderate band specifically: Rosuvastatin/Ezetimibe has 7 (also Rosuvastatin, Cyclosporine, Colchicine, Gemfibrozil); Ledipasvir/Sofosbuvir has 5 (also Atorvastatin, Rifampin, Amiodarone, Rosuvastatin).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Ledipasvir/Sofosbuvir?
These medications can cause rosuvastatin to build up in your system, which increases the risk of harmful side effects.
Rosuvastatin/Ezetimibe carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)).
Rosuvastatin/Ezetimibe has 3 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 2 minor · 12 total
- Other moderate peers for Rosuvastatin/Ezetimibe
- Rosuvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
0 major · 5 moderate · 17 minor · 22 total
- Other moderate peers for Ledipasvir/Sofosbuvir
- Atorvastatin
- Rifampin
- Amiodarone
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.