Rosuvastatin/Ezetimibe and Febuxostat Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Febuxostat.
Rosuvastatin/Ezetimibe and Febuxostat have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rosuvastatin/Ezetimibe and Febuxostat. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Febuxostat interferes with the way your body handles rosuvastatin, which can nearly double the amount of the drug in your bloodstream. This buildup increases the chance of experiencing harmful side effects.
FDA Label Information
Febuxostat Clinical Impact: Febuxostat increased rosuvastatin exposure more than 1.9-fold. Intervention: In patients taking febuxostat, do not exceed a dose of rosuvastatin 20 mg once daily.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Rosuvastatin moderate
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Febuxostat Also Interacts With
- Rosuvastatin major
- Theophylline moderate
- Hydrochlorothiazide minor
- Naproxen minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Febuxostat?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin/Ezetimibe has 12 labeled pairs on file vs Febuxostat's 9. In the major band specifically: Rosuvastatin/Ezetimibe has 3 (also Sofosbuvir/Velpatasvir, Glecaprevir/Pibrentasvir); Febuxostat has 2 (also Rosuvastatin).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Febuxostat?
Febuxostat interferes with the way your body handles rosuvastatin, which can nearly double the amount of the drug in your bloodstream. This buildup increases the chance of experiencing harmful side effects.
Rosuvastatin/Ezetimibe carries more major-labeled pairs than Febuxostat
SPL source-record counts only. This page's band is major · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Febuxostat (Xanthine Oxidase Inhibitor).
Rosuvastatin/Ezetimibe has 3 major-labeled pairs vs Febuxostat's 2.
3 major · 7 moderate · 2 minor · 12 total
- Other major peers for Rosuvastatin/Ezetimibe
- Sofosbuvir/Velpatasvir
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.