Rosuvastatin/Ezetimibe and Rosuvastatin Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Rosuvastatin.
Rosuvastatin/Ezetimibe and Rosuvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin/Ezetimibe and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Antacids can stop your body from properly absorbing rosuvastatin if they are taken too close together.
FDA Label Information
7 DRUG INTERACTIONS See full prescribing information for details regarding concomitant use of rosuvastatin with other drugs that increase the risk of myopathy and rhabdomyolysis. ( 7.1 ) Aluminum and Magnesium Hydroxide Combination Antacids : Administer rosuvastatin at least 2 hours before the antacid. ( 7.2 ) Warfarin : Obtain INR prior to starting rosuvastatin.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Rosuvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the moderate band specifically: Rosuvastatin/Ezetimibe has 7 (also Cyclosporine, Ledipasvir/Sofosbuvir, Colchicine, Gemfibrozil); Rosuvastatin has 8 (also Cyclosporine, Ledipasvir/Sofosbuvir, Colchicine, Gemfibrozil).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Rosuvastatin?
Antacids can stop your body from properly absorbing rosuvastatin if they are taken too close together.
Rosuvastatin's labeled portfolio outnumbers Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
3 major · 7 moderate · 2 minor · 12 total
- Other moderate peers for Rosuvastatin/Ezetimibe
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Colchicine
- Gemfibrozil
3 major · 8 moderate · 10 minor · 21 total
- Other moderate peers for Rosuvastatin
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Colchicine
- Gemfibrozil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.