Rosuvastatin/Ezetimibe and Sofosbuvir/Velpatasvir Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Sofosbuvir/Velpatasvir.
Rosuvastatin/Ezetimibe and Sofosbuvir/Velpatasvir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rosuvastatin/Ezetimibe and Sofosbuvir/Velpatasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antiviral medicine increases the amount of rosuvastatin in your system by changing how your body processes it. Higher levels of the drug can increase the risk of muscle damage.
FDA Label Information
Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.
Rosuvastatin/Ezetimibe Also Interacts With
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Pravastatin moderate
- Methotrexate moderate
- Cyclosporine moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Sofosbuvir/Velpatasvir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sofosbuvir/Velpatasvir has 33 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the major band specifically: Rosuvastatin/Ezetimibe has 3 (also Glecaprevir/Pibrentasvir, Febuxostat); Sofosbuvir/Velpatasvir has 3 (also Rifampin, Rosuvastatin).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Sofosbuvir/Velpatasvir?
This antiviral medicine increases the amount of rosuvastatin in your system by changing how your body processes it. Higher levels of the drug can increase the risk of muscle damage.
Sofosbuvir/Velpatasvir's labeled portfolio outnumbers Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is major · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)).
3 major · 7 moderate · 2 minor · 12 total
- Other major peers for Rosuvastatin/Ezetimibe
- Glecaprevir/Pibrentasvir
- Febuxostat
3 major · 10 moderate · 20 minor · 33 total
- Other major peers for Sofosbuvir/Velpatasvir
- Rifampin
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.