Rosuvastatin/Ezetimibe and Gemfibrozil Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Gemfibrozil.
Rosuvastatin/Ezetimibe and Gemfibrozil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin/Ezetimibe and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil raises the amount of rosuvastatin in your blood, and both drugs can cause muscle damage on their own. This combination significantly increases the risk of serious muscle breakdown.
FDA Label Information
The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine or gemfibrozil with rosuvastatin. Gemfibrozil Clinical Impact: Gemfibrozil significantly increased rosuvastatin exposure and gemfibrozil may cause myopathy when given alone. The risk of myopathy and rhabdomyolysis is increased with concomitant use of gemfibrozil with rosuvastatin.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Gemfibrozil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the moderate band specifically: Rosuvastatin/Ezetimibe has 7 (also Rosuvastatin, Cyclosporine, Ledipasvir/Sofosbuvir, Colchicine); Gemfibrozil has 8 (also Atorvastatin, Eluxadoline, Fluvastatin, Lovastatin).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Gemfibrozil?
Gemfibrozil raises the amount of rosuvastatin in your blood, and both drugs can cause muscle damage on their own. This combination significantly increases the risk of serious muscle breakdown.
Gemfibrozil carries more major-labeled pairs than Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Rosuvastatin/Ezetimibe's 3. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 2 minor · 12 total
- Other moderate peers for Rosuvastatin/Ezetimibe
- Rosuvastatin
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Colchicine
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Eluxadoline
- Fluvastatin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.