Rosuvastatin/Ezetimibe and Cyclosporine Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Cyclosporine.
Rosuvastatin/Ezetimibe and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin/Ezetimibe and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine causes rosuvastatin levels to rise significantly, which increases the danger of severe muscle damage.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Ledipasvir/Sofosbuvir moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the moderate band specifically: Rosuvastatin/Ezetimibe has 7 (also Rosuvastatin, Ledipasvir/Sofosbuvir, Colchicine, Gemfibrozil); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Cyclosporine?
Cyclosporine causes rosuvastatin levels to rise significantly, which increases the danger of severe muscle damage.
Cyclosporine carries more major-labeled pairs than Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Rosuvastatin/Ezetimibe's 3. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 2 minor · 12 total
- Other moderate peers for Rosuvastatin/Ezetimibe
- Rosuvastatin
- Ledipasvir/Sofosbuvir
- Colchicine
- Gemfibrozil
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.