Rosuvastatin/Ezetimibe and Colchicine Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Colchicine.
Rosuvastatin/Ezetimibe and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin/Ezetimibe and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together increases the risk of serious muscle damage and breakdown.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with rosuvastatin. Intervention: Consider if the benefit of using colchicine concomitantly with rosuvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Colchicine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the moderate band specifically: Rosuvastatin/Ezetimibe has 7 (also Rosuvastatin, Cyclosporine, Ledipasvir/Sofosbuvir, Gemfibrozil); Colchicine has 9 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fenofibrate).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Colchicine?
Taking these two drugs together increases the risk of serious muscle damage and breakdown.
Colchicine carries more major-labeled pairs than Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Colchicine (Anti-Gout Agent).
Colchicine has 4 major-labeled pairs vs Rosuvastatin/Ezetimibe's 3. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 2 minor · 12 total
- Other moderate peers for Rosuvastatin/Ezetimibe
- Rosuvastatin
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Gemfibrozil
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fenofibrate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.