rosuvastatin/ezetimibe

Name: rosuvastatin/ezetimibe — FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Reviewed byPlainmeds Editorial, Drug Information Editorial Team · June 5, 2026

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Brand names: Roszet

Statin / Cholesterol Absorption Inhibitor Rx

Roszet contains rosuvastatin, which is a statin medicine. It helps lower bad cholesterol and reduce the risk of heart problems.

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What it does

This medicine can help lower LDL cholesterol (bad cholesterol) if you have high cholesterol.

Common side effects

Headache, Nausea, Muscle pain

Key warnings

Rosuvastatin can sometimes cause muscle problems, including rhabdomyolysis.

How It Works

Rosuvastatin blocks a substance your body needs to make cholesterol. This lowers the amount of cholesterol in your blood. It helps prevent heart attacks and strokes.

How to Take It

Take Roszet once a day, with or without food. You can take it at any time of day. Try to take it at the same time each day. Your doctor may change your dose based on your cholesterol levels.

Pregnancy & Breastfeeding

Rosuvastatin can harm your unborn baby. Do not take this medicine if you are pregnant. Breastfeeding is also not recommended while taking rosuvastatin.

Missed Dose

If you miss a dose, just take your next dose at the regular time. Do not take an extra dose to make up for the missed one.

Storage

Store Roszet at room temperature, away from moisture.

Side Effects (from patient reports)

Based on 90,610 FDA adverse event reports.

Tiredness

11,698

Feeling sick to your stomach

10,037

Medicine not working

9,223

Difficulty breathing

9,212

Loose stools

9,199

Muscle pain

8,784

Using medicine for something not approved

8,522

General pain

8,419

Head pain

7,798

Feeling lightheaded

7,718

Serious Warnings

Rosuvastatin can sometimes cause muscle problems, including rhabdomyolysis. This can damage your kidneys. Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel sick. This medicine can also cause liver problems. Your doctor may do blood tests to check your liver.

Known Drug Interactions

major sofosbuvir/velpatasvir

Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.

Mechanism: This antiviral medicine increases the amount of rosuvastatin in your system by changing how your body processes it. Higher levels of the drug can increase the risk of muscle damage.

What to do: You should start with a low 5 mg dose of rosuvastatin and never take more than 10 mg daily while using this combination.

major glecaprevir/pibrentasvir

Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.

Mechanism: These hepatitis C drugs block the pathways your body uses to remove rosuvastatin, leading to higher levels of the statin in your blood. This can increase your risk for serious side effects.

What to do: Your doctor should start your rosuvastatin at 5 mg daily and keep the dose at or below 10 mg per day.

major febuxostat

Febuxostat Clinical Impact: Febuxostat increased rosuvastatin exposure more than 1.9-fold. Intervention: In patients taking febuxostat, do not exceed a dose of rosuvastatin 20 mg once daily.

Mechanism: Febuxostat interferes with the way your body handles rosuvastatin, which can nearly double the amount of the drug in your bloodstream. This buildup increases the chance of experiencing harmful side effects.

What to do: When taking these two drugs together, ensure your rosuvastatin dose does not exceed 20 mg once daily.

moderate rosuvastatin

7 DRUG INTERACTIONS See full prescribing information for details regarding concomitant use of rosuvastatin with other drugs that increase the risk of myopathy and rhabdomyolysis. ( 7.1 ) Aluminum and Magnesium Hydroxide Combination Antacids : Administer rosuvastatin at least 2 hours before the antacid. ( 7.2 ) Warfarin : Obtain INR prior to starting rosuvastatin.

Mechanism: Antacids can stop your body from properly absorbing rosuvastatin if they are taken too close together.

What to do: Make sure to take your rosuvastatin at least two hours before you take any antacids.

moderate cyclosporine

Table 5: Drug Interactions that Increase the Risk of Myopathy and Rhabdomyolysis with Rosuvastatin Cyclosporine Clinical Impact: Cyclosporine increased rosuvastatin exposure 7-fold. The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine or gemfibrozil with rosuvastatin.

Mechanism: Cyclosporine causes rosuvastatin levels to rise significantly, which increases the danger of severe muscle damage.

What to do: This combination increases the risk of muscle breakdown, so your doctor may need to adjust your treatment or avoid using them together.

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Common Questions

Can I take Roszet with food?

Yes, you can take Roszet with or without food.

What should I do if I have muscle pain?

Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness.

Can I drink alcohol while taking Roszet?

Talk to your doctor about drinking alcohol while taking Roszet.

How long will I need to take Roszet?

You may need to take Roszet long-term to manage your cholesterol.

Will I need blood tests while taking Roszet?

Yes, your doctor will likely do blood tests to check your cholesterol and liver function.

Can I stop taking Roszet if my cholesterol is better?

Do not stop taking Roszet without talking to your doctor first.

What if I am Asian?

Your doctor may start you on a lower dose of 5 mg daily.

Can I take antacids with Roszet?

Take Roszet at least 2 hours before taking an antacid.

What happens if I have kidney problems?

Your doctor may start you on a lower dose of 5 mg daily and not exceed 10mg daily.

What are the different strengths of Roszet?

Roszet comes in 5 mg, 10 mg, 20 mg, and 40 mg tablets.

What are the common side effects of rosuvastatin/ezetimibe?

The most commonly reported side effects of rosuvastatin/ezetimibe include Headache, Nausea, Muscle pain, Weakness, Constipation. Based on 90,610 FDA adverse event reports. Always consult your healthcare provider about potential side effects.

Does rosuvastatin/ezetimibe interact with other medications?

Yes, rosuvastatin/ezetimibe has 12 known drug interactions. Notable interactions include sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, febuxostat. Always inform your doctor about all medications you are taking.

What drug class is rosuvastatin/ezetimibe?

rosuvastatin/ezetimibe belongs to the Statin / Cholesterol Absorption Inhibitor drug class. It requires a prescription (Rx). This medicine can help lower LDL cholesterol (bad cholesterol) if you have high cholesterol.

Is rosuvastatin/ezetimibe safe during pregnancy?

Rosuvastatin can harm your unborn baby. Do not take this medicine if you are pregnant. Always consult your healthcare provider before using any medication during pregnancy or breastfeeding.

Related Medications in Statin / Cholesterol Absorption Inhibitor

Other drugs grouped near rosuvastatin/ezetimibe — same-class peers and common alternatives.

alirocumab

Praluent

Praluent is a medicine that can lower cholesterol.