Rosuvastatin/Ezetimibe and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Glecaprevir/Pibrentasvir.
Rosuvastatin/Ezetimibe and Glecaprevir/Pibrentasvir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rosuvastatin/Ezetimibe and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These hepatitis C drugs block the pathways your body uses to remove rosuvastatin, leading to higher levels of the statin in your blood. This can increase your risk for serious side effects.
FDA Label Information
Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Cyclosporine moderate
- Darunavir moderate
- Estradiol moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the major band specifically: Rosuvastatin/Ezetimibe has 3 (also Sofosbuvir/Velpatasvir, Febuxostat); Glecaprevir/Pibrentasvir has 3 (also Rifampin, Rosuvastatin).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Glecaprevir/Pibrentasvir?
These hepatitis C drugs block the pathways your body uses to remove rosuvastatin, leading to higher levels of the statin in your blood. This can increase your risk for serious side effects.
Glecaprevir/Pibrentasvir's labeled portfolio outnumbers Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is major · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
3 major · 7 moderate · 2 minor · 12 total
- Other major peers for Rosuvastatin/Ezetimibe
- Sofosbuvir/Velpatasvir
- Febuxostat
3 major · 9 moderate · 26 minor · 38 total
- Other major peers for Glecaprevir/Pibrentasvir
- Rifampin
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.