Colchicine and Ezetimibe Interaction
Drug interaction information between Colchicine and Ezetimibe.
Colchicine and Ezetimibe have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Colchicine and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can lead to severe muscle damage and breakdown. Both drugs have side effects that affect the muscles, and combining them makes this more likely.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with ezetimibe and simvastatin. Intervention: Consider if the benefit of using colchicine concomitantly with ezetimibe and simvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Ezetimibe?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Ezetimibe's 25. In the moderate band specifically: Colchicine has 9 (also Atorvastatin, Ezetimibe/Simvastatin, Fenofibrate, Pitavastatin); Ezetimibe has 4 (also Daptomycin, Niacin, Simvastatin).
What mechanism field is on file for Colchicine and Ezetimibe?
Using these drugs together can lead to severe muscle damage and breakdown. Both drugs have side effects that affect the muscles, and combining them makes this more likely.
Ezetimibe carries more major-labeled pairs than Colchicine
SPL source-record counts only. This page's band is moderate · classes on file: Colchicine (Anti-Gout Agent); Ezetimibe (Cholesterol Absorption Inhibitor).
Ezetimibe has 8 major-labeled pairs vs Colchicine's 4. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe/Simvastatin
- Fenofibrate
- Pitavastatin
8 major · 4 moderate · 13 minor · 25 total
- Other moderate peers for Ezetimibe
- Daptomycin
- Niacin
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.