Colchicine and Ezetimibe Interaction
Drug interaction information between Colchicine and Ezetimibe.
Colchicine and Ezetimibe have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Colchicine and Ezetimibe. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using these drugs together can lead to severe muscle damage and breakdown. Both drugs have side effects that affect the muscles, and combining them makes this more likely.
What To Do
Talk to your doctor about whether the benefits of taking both drugs are worth the increased risk of muscle damage. Report any new or unexplained muscle aches or tiredness right away.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with ezetimibe and simvastatin. Intervention: Consider if the benefit of using colchicine concomitantly with ezetimibe and simvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
Can I take Colchicine and Ezetimibe together?
This is a moderate interaction. Talk to your doctor about whether the benefits of taking both drugs are worth the increased risk of muscle damage. Report any new or unexplained muscle aches or tiredness right away.
How serious is the interaction between Colchicine and Ezetimibe?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Colchicine and Ezetimibe interact?
Using these drugs together can lead to severe muscle damage and breakdown. Both drugs have side effects that affect the muscles, and combining them makes this more likely.
Understanding the Colchicine and Ezetimibe Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Colchicine belongs to the Anti-Gout Agent class and Ezetimibe belongs to the Cholesterol Absorption Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using these drugs together can lead to severe muscle damage and breakdown. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Colchicine has 28 total documented interactions on file in this dataset, and Ezetimibe has 25. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Talk to your doctor about whether the benefits of taking both drugs are worth the increased risk of muscle damage. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Colchicine or Ezetimibe based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.