Colchicine and Fenofibrate Interaction
Drug interaction information between Colchicine and Fenofibrate.
Colchicine and Fenofibrate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Colchicine and Fenofibrate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can lead to a higher risk of severe muscle pain and muscle breakdown.
FDA Label Information
7.4 Colchicine Cases of myopathy, including rhabdomyolysis, have been reported with fenofibrates co administered with colchicine, and caution should be exercised when prescribing fenofibrate with colchicine.
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Fenofibrate Also Interacts With
- Cyclosporine moderate
- Bempedoic Acid moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
- Ezetimibe/Simvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Fenofibrate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Fenofibrate's 9. In the moderate band specifically: Colchicine has 9 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Pitavastatin); Fenofibrate has 4 (also Cyclosporine, Bempedoic Acid, Bempedoic Acid/Ezetimibe).
What mechanism field is on file for Colchicine and Fenofibrate?
Combining these drugs can lead to a higher risk of severe muscle pain and muscle breakdown.
Colchicine carries more major-labeled pairs than Fenofibrate
SPL source-record counts only. This page's band is moderate · classes on file: Colchicine (Anti-Gout Agent); Fenofibrate (Fibrate).
Colchicine has 4 major-labeled pairs vs Fenofibrate's 0. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Pitavastatin
0 major · 4 moderate · 5 minor · 9 total
- Other moderate peers for Fenofibrate
- Cyclosporine
- Bempedoic Acid
- Bempedoic Acid/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.