Colchicine and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Colchicine and Nirmatrelvir/Ritonavir.
Colchicine and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Colchicine and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir stops the body from processing colchicine, which can cause the drug to reach toxic levels. This is very dangerous and can be life-threatening, especially for people with liver or kidney disease.
FDA Label Information
Anti-gout colchicine ↑ colchicine Co-administration contraindicated due to potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment [see Contraindications (4) ] .
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Atorvastatin moderate
- Ezetimibe moderate
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Colchicine's 28. In the major band specifically: Colchicine has 4 (also Clarithromycin, Darunavir, Itraconazole); Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Colchicine and Nirmatrelvir/Ritonavir?
Ritonavir stops the body from processing colchicine, which can cause the drug to reach toxic levels. This is very dangerous and can be life-threatening, especially for people with liver or kidney disease.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Colchicine
SPL source-record counts only. This page's band is major · classes on file: Colchicine (Anti-Gout Agent); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Colchicine's 4.
4 major · 9 moderate · 15 minor · 28 total
- Other major peers for Colchicine
- Clarithromycin
- Darunavir
- Itraconazole
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.