Colchicine and Darunavir Interaction
Drug interaction information between Colchicine and Darunavir.
Colchicine and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Colchicine and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir makes it harder for your body to get rid of colchicine, which can cause the medicine to reach toxic levels. This is especially dangerous for people with liver or kidney problems.
FDA Label Information
Anti-gout: colchicine ↑ colchicine Co-administration is contraindicated in patients with renal and/or hepatic impairment due to potential for serious and/or life-threatening reactions. For patients without renal or hepatic impairment: Treatment of gout-flares – co-administration of colchicine in patients on darunavir/ritonavir: 0.6 mg (1 tablet) × 1 dose, followed by 0.3 mg (half tablet) 1 hour later. Prophylaxis of gout-flares – co-administration of colchicine in patients on darunavir/ritonavir: If the original regimen was 0.6 mg twice a day, the regimen should be adjusted to 0.3 mg once...
Colchicine Also Interacts With
- Clarithromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
- Ezetimibe moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Colchicine's 28. In the major band specifically: Colchicine has 4 (also Clarithromycin, Itraconazole, Nirmatrelvir/Ritonavir); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Colchicine and Darunavir?
Darunavir makes it harder for your body to get rid of colchicine, which can cause the medicine to reach toxic levels. This is especially dangerous for people with liver or kidney problems.
Darunavir carries more major-labeled pairs than Colchicine
SPL source-record counts only. This page's band is major · classes on file: Colchicine (Anti-Gout Agent); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Colchicine's 4.
4 major · 9 moderate · 15 minor · 28 total
- Other major peers for Colchicine
- Clarithromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.