Colchicine and Darunavir Interaction
Drug interaction information between Colchicine and Darunavir.
Colchicine and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Colchicine and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir makes it harder for your body to get rid of colchicine, which can cause the medicine to reach toxic levels. This is especially dangerous for people with liver or kidney problems.
What To Do
People with liver or kidney disease must avoid this combination. Others will need their doctor to carefully lower their colchicine dose.
FDA Label Information
Anti-gout: colchicine ↑ colchicine Co-administration is contraindicated in patients with renal and/or hepatic impairment due to potential for serious and/or life-threatening reactions. For patients without renal or hepatic impairment: Treatment of gout-flares – co-administration of colchicine in patients on darunavir/ritonavir: 0.6 mg (1 tablet) × 1 dose, followed by 0.3 mg (half tablet) 1 hour later. Prophylaxis of gout-flares – co-administration of colchicine in patients on darunavir/ritonavir: If the original regimen was 0.6 mg twice a day, the regimen should be adjusted to 0.3 mg once...
Colchicine Also Interacts With
- Clarithromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
- Ezetimibe moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Colchicine and Darunavir together?
This is a major interaction. People with liver or kidney disease must avoid this combination. Others will need their doctor to carefully lower their colchicine dose.
How serious is the interaction between Colchicine and Darunavir?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Colchicine and Darunavir interact?
Darunavir makes it harder for your body to get rid of colchicine, which can cause the medicine to reach toxic levels. This is especially dangerous for people with liver or kidney problems.
Understanding the Colchicine and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Colchicine belongs to the Anti-Gout Agent class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir makes it harder for your body to get rid of colchicine, which can cause the medicine to reach toxic levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Colchicine has 28 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: People with liver or kidney disease must avoid this combination. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Colchicine or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.