Ranolazine and Verapamil Interaction
Drug interaction information between Ranolazine and Verapamil.
Ranolazine and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranolazine and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil makes it harder for your body to clear ranolazine, which can increase the risk of side effects.
FDA Label Information
7 DRUG INTERACTIONS Moderate CYP3A inhibitors (e.g., diltiazem, verapamil, erythromycin): Limit ranolazine to 500 mg twice daily. Moderate CYP3A Inhibitors Limit the dose of ranolazine to 500 mg twice daily in patients on moderate CYP3A inhibitors, including diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice or grapefruit-containing products [see Dosage and Administration (2.2) , Clinical Pharmacology (12.3) ].
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Ranolazine's 31. In the minor band specifically: Ranolazine has 12 (also Diltiazem, Fluconazole, Cyclosporine, Erythromycin); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Ranolazine and Verapamil?
Verapamil makes it harder for your body to clear ranolazine, which can increase the risk of side effects.
Ranolazine carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is minor · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Verapamil (Calcium Channel Blocker).
Ranolazine has 12 major-labeled pairs vs Verapamil's 4. This page itself is in the minor band, not the major band.
12 major · 7 moderate · 12 minor · 31 total
- Other minor peers for Ranolazine
- Diltiazem
- Fluconazole
- Cyclosporine
- Erythromycin
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.