Ranolazine and Erythromycin Interaction
Drug interaction information between Ranolazine and Erythromycin.
Ranolazine and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranolazine and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down the process your body uses to get rid of ranolazine. This can cause the amount of ranolazine in your blood to rise.
FDA Label Information
7 DRUG INTERACTIONS Moderate CYP3A inhibitors (e.g., diltiazem, verapamil, erythromycin): Limit ranolazine to 500 mg twice daily. Moderate CYP3A Inhibitors Limit the dose of ranolazine to 500 mg twice daily in patients on moderate CYP3A inhibitors, including diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice or grapefruit-containing products [see Dosage and Administration (2.2) , Clinical Pharmacology (12.3) ].
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Ranolazine's 31. In the minor band specifically: Ranolazine has 12 (also Diltiazem, Fluconazole, Verapamil, Cyclosporine); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Ranolazine and Erythromycin?
Erythromycin slows down the process your body uses to get rid of ranolazine. This can cause the amount of ranolazine in your blood to rise.
Ranolazine carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is minor · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Erythromycin (Macrolide Antibiotic).
Ranolazine has 12 major-labeled pairs vs Erythromycin's 4. This page itself is in the minor band, not the major band.
12 major · 7 moderate · 12 minor · 31 total
- Other minor peers for Ranolazine
- Diltiazem
- Fluconazole
- Verapamil
- Cyclosporine
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.