Ranolazine and Clarithromycin Interaction
Drug interaction information between Ranolazine and Clarithromycin.
Ranolazine and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ranolazine and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the enzyme that normally clears ranolazine from your system, leading to a dangerous buildup of the medication.
FDA Label Information
( 7.2 ) 7.1 Effects of Other Drugs on Ranolazine Strong CYP3A Inhibitors Do not use ranolazine with strong CYP3A inhibitors, including ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, and saquinavir [see Contraindications (4) , Clinical Pharmacology (12.3) ].
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Rifampin major
- Phenytoin major
- Phenobarbital major
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Ranolazine's 31. In the major band specifically: Ranolazine has 12 (also Ketoconazole, Carbamazepine, Rifampin, Phenytoin); Clarithromycin has 16 (also Quetiapine, Pioglitazone, Fluconazole, Cyclosporine).
What mechanism field is on file for Ranolazine and Clarithromycin?
Clarithromycin blocks the enzyme that normally clears ranolazine from your system, leading to a dangerous buildup of the medication.
Clarithromycin carries more major-labeled pairs than Ranolazine
SPL source-record counts only. This page's band is major · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Ranolazine's 12.
12 major · 7 moderate · 12 minor · 31 total
- Other major peers for Ranolazine
- Ketoconazole
- Carbamazepine
- Rifampin
- Phenytoin
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Fluconazole
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.