Ranolazine and Rifampin Interaction
Drug interaction information between Ranolazine and Rifampin.
Ranolazine and Rifampin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ranolazine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the liver enzymes that break down ranolazine, which can make the ranolazine stop working.
FDA Label Information
CYP3A Inducers Do not use ranolazine with CYP3A inducers such as rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, and St.
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Phenytoin major
- Phenobarbital major
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Rifampin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Ranolazine's 31. In the major band specifically: Ranolazine has 12 (also Ketoconazole, Carbamazepine, Clarithromycin, Phenytoin); Rifampin has 8 (also Darunavir, Bictegravir, Glecaprevir/Pibrentasvir, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Ranolazine and Rifampin?
Rifampin speeds up the liver enzymes that break down ranolazine, which can make the ranolazine stop working.
Ranolazine carries more major-labeled pairs than Rifampin
SPL source-record counts only. This page's band is major · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Rifampin (Rifamycin Antibiotic).
Ranolazine has 12 major-labeled pairs vs Rifampin's 8.
12 major · 7 moderate · 12 minor · 31 total
- Other major peers for Ranolazine
- Ketoconazole
- Carbamazepine
- Clarithromycin
- Phenytoin
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Darunavir
- Bictegravir
- Glecaprevir/Pibrentasvir
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.