Ranolazine and Cyclosporine Interaction
Drug interaction information between Ranolazine and Cyclosporine.
Ranolazine and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranolazine and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine blocks a protein that helps remove ranolazine from the body, and both drugs can affect how the other is processed.
FDA Label Information
( 7.1 ) P-gp inhibitors (e.g., cyclosporine): Ranolazine exposure increased. Doses of other sensitive CYP3A substrates (e.g., lovastatin) and CYP3A substrates with narrow therapeutic range (e.g., cyclosporine, tacrolimus, sirolimus) may need to be reduced with ranolazine. P-gp Inhibitors Concomitant use of ranolazine and P-gp inhibitors, such as cyclosporine, may result in increases in ranolazine concentrations.
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Ranolazine's 31. In the minor band specifically: Ranolazine has 12 (also Diltiazem, Fluconazole, Verapamil, Erythromycin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Ranolazine and Cyclosporine?
Cyclosporine blocks a protein that helps remove ranolazine from the body, and both drugs can affect how the other is processed.
Ranolazine carries more major-labeled pairs than Cyclosporine
SPL source-record counts only. This page's band is minor · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Ranolazine has 12 major-labeled pairs vs Cyclosporine's 5. This page itself is in the minor band, not the major band.
12 major · 7 moderate · 12 minor · 31 total
- Other minor peers for Ranolazine
- Diltiazem
- Fluconazole
- Verapamil
- Erythromycin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.