Ranolazine and Fluconazole Interaction
Drug interaction information between Ranolazine and Fluconazole.
Ranolazine and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranolazine and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the natural process your body uses to break down ranolazine, leading to more medicine in your blood.
FDA Label Information
Moderate CYP3A Inhibitors Limit the dose of ranolazine to 500 mg twice daily in patients on moderate CYP3A inhibitors, including diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice or grapefruit-containing products [see Dosage and Administration (2.2) , Clinical Pharmacology (12.3) ].
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Ranolazine's 31. In the minor band specifically: Ranolazine has 12 (also Diltiazem, Verapamil, Cyclosporine, Erythromycin); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Ranolazine and Fluconazole?
Fluconazole blocks the natural process your body uses to break down ranolazine, leading to more medicine in your blood.
Ranolazine carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is minor · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Fluconazole (Azole Antifungal).
Ranolazine has 12 major-labeled pairs vs Fluconazole's 3. This page itself is in the minor band, not the major band.
12 major · 7 moderate · 12 minor · 31 total
- Other minor peers for Ranolazine
- Diltiazem
- Verapamil
- Cyclosporine
- Erythromycin
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.