Ranitidine and Clonazepam Interaction
Drug interaction information between Ranitidine and Clonazepam.
Ranitidine and Clonazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranitidine and Clonazepam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Ranitidine reduces stomach acid but does not have a major effect on how clonazepam moves through your body.
What To Do
No specific action is typically required when taking these medications together.
FDA Label Information
Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Darunavir minor
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
Frequently Asked Questions
Can I take Ranitidine and Clonazepam together?
This is a minor interaction. No specific action is typically required when taking these medications together.
How serious is the interaction between Ranitidine and Clonazepam?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Ranitidine and Clonazepam interact?
Ranitidine reduces stomach acid but does not have a major effect on how clonazepam moves through your body.
Understanding the Ranitidine and Clonazepam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Ranitidine belongs to the H2 Receptor Antagonist class and Clonazepam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Ranitidine reduces stomach acid but does not have a major effect on how clonazepam moves through your body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ranitidine has 15 total documented interactions on file in this dataset, and Clonazepam has 14. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No specific action is typically required when taking these medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ranitidine or Clonazepam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.