Ranitidine and Clonazepam Interaction
Drug interaction information between Ranitidine and Clonazepam.
Ranitidine and Clonazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranitidine and Clonazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine reduces stomach acid but does not have a major effect on how clonazepam moves through your body.
FDA Label Information
Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Darunavir minor
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Ranitidine + Clonazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranitidine has 15 labeled pairs on file vs Clonazepam's 14. In the minor band specifically: Ranitidine has 11 (also Darunavir, Diltiazem, Eprosartan, Ibandronate); Clonazepam has 10 (also Lamotrigine, Fluconazole, Carbamazepine, Phenytoin).
What mechanism field is on file for Ranitidine and Clonazepam?
Ranitidine reduces stomach acid but does not have a major effect on how clonazepam moves through your body.
Ranitidine's labeled portfolio outnumbers Clonazepam
SPL source-record counts only. This page's band is minor · classes on file: Ranitidine (H2 Receptor Antagonist); Clonazepam (Benzodiazepine).
3 major · 1 moderate · 11 minor · 15 total
- Other minor peers for Ranitidine
- Darunavir
- Diltiazem
- Eprosartan
- Ibandronate
3 major · 1 moderate · 10 minor · 14 total
- Other minor peers for Clonazepam
- Lamotrigine
- Fluconazole
- Carbamazepine
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.