Clonazepam and Fluoxetine Interaction
Drug interaction information between Clonazepam and Fluoxetine.
Clonazepam and Fluoxetine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Clonazepam and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine does not interfere with how your body breaks down or uses clonazepam.
FDA Label Information
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Clonazepam Also Interacts With
- Sertraline major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
- Fluconazole minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Fluoxetine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Clonazepam's 14. In the major band specifically: Clonazepam has 3 (also Sertraline, Felbamate); Fluoxetine has 6 (also Aspirin, Warfarin, Olanzapine, Pimozide).
What mechanism field is on file for Clonazepam and Fluoxetine?
Fluoxetine does not interfere with how your body breaks down or uses clonazepam.
Fluoxetine carries more major-labeled pairs than Clonazepam
SPL source-record counts only. This page's band is major · classes on file: Clonazepam (Benzodiazepine); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Clonazepam's 3.
3 major · 1 moderate · 10 minor · 14 total
- Other major peers for Clonazepam
- Sertraline
- Felbamate
6 major · 19 moderate · 43 minor · 68 total
- Other major peers for Fluoxetine
- Aspirin
- Warfarin
- Olanzapine
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.