Clonazepam and Felbamate Interaction
Drug interaction information between Clonazepam and Felbamate.
Clonazepam and Felbamate have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Clonazepam and Felbamate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Felbamate does not change the levels of clonazepam in the body or how it is processed.
FDA Label Information
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Diazepam moderate
- Lamotrigine minor
- Fluconazole minor
Felbamate Also Interacts With
- Erythromycin minor
- Phenobarbital minor
- Carbamazepine minor
- Drospirenone/Ethinyl Estradiol minor
- Estradiol minor
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Felbamate?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Felbamate has 16 labeled pairs on file vs Clonazepam's 14. In the major band specifically: Clonazepam has 3 (also Sertraline, Fluoxetine); Felbamate has 1.
What mechanism field is on file for Clonazepam and Felbamate?
Felbamate does not change the levels of clonazepam in the body or how it is processed.
Clonazepam carries more major-labeled pairs than Felbamate
SPL source-record counts only. This page's band is major · classes on file: Clonazepam (Benzodiazepine); Felbamate (Anticonvulsant).
Clonazepam has 3 major-labeled pairs vs Felbamate's 1.
3 major · 1 moderate · 10 minor · 14 total
- Other major peers for Clonazepam
- Sertraline
- Fluoxetine
1 major · 0 moderate · 15 minor · 16 total
Felbamate has no other major-band peer in this dataset besides Clonazepam.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.