What the FDA labels say about taking them together
Clonazepam and felbamate
Clonazepam's FDA label of December 1, 2025 names felbamate in its drug interactions section; the felbamate label PlainMeds reads does not name clonazepam. The clonazepam label: “The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate do not affect the pharmacokinetics of clonazepam.”
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the felbamate FDA label on DailyMed (effective August 15, 2025, Viatris Specialty LLC).
What does the clonazepam label say about felbamate?
Clonazepam label, drug interactionsThe selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the felbamate label say about clonazepam?
Felbamate's label (effective August 15, 2025) does not name clonazepam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Felbatol), NDA020189 (Mylan Speciality Lp), as published by Viatris Specialty LLC, effective August 15, 2025 (SPL set 2f522701-397a-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Felbamate | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | $1.00 per tablet 600 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once