Ranitidine and Diltiazem Interaction
Drug interaction information between Ranitidine and Diltiazem.
Ranitidine and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranitidine and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine can cause a slight increase in diltiazem levels, though the change is usually not large enough to be dangerous.
FDA Label Information
Ranitidine produced smaller, nonsignificant increases.
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Clonazepam minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Ranitidine + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Ranitidine's 15. In the minor band specifically: Ranitidine has 11 (also Clonazepam, Darunavir, Eprosartan, Ibandronate); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Ranitidine and Diltiazem?
Ranitidine can cause a slight increase in diltiazem levels, though the change is usually not large enough to be dangerous.
Diltiazem carries more major-labeled pairs than Ranitidine
SPL source-record counts only. This page's band is minor · classes on file: Ranitidine (H2 Receptor Antagonist); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Ranitidine's 3. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 11 minor · 15 total
- Other minor peers for Ranitidine
- Clonazepam
- Darunavir
- Eprosartan
- Ibandronate
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.