Ranitidine and Risperidone Interaction
Drug interaction information between Ranitidine and Risperidone.
Ranitidine and Risperidone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ranitidine and Risperidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine causes a small increase in risperidone levels, but it is not enough to change how the drug works or its safety.
FDA Label Information
Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] . Do not exceed twice the patient’s usual dose Enzyme (CYP3A) inhibitors Ranitidine 150 mg twice daily 1 mg single dose 1.2 1.4 Dose adjustment not needed Cimetidine 400 mg twice daily 1 mg single dose 1.1 1.3 Dose adjustment not needed Erythromycin 500 mg four times daily 1 mg single dose 1.1 0.94 Dose adjustment not needed Other Drugs Amitriptyline 50 mg twice daily 3 mg twice daily 1.2 1.1 Dose adjustment not Needed *Change relative...
Ranitidine Also Interacts With
- Theophylline major
- Valproate major
- Midazolam moderate
- Clonazepam minor
- Darunavir minor
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Cimetidine major
Frequently Asked Questions
What SPL severity band is on file for Ranitidine + Risperidone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Risperidone has 20 labeled pairs on file vs Ranitidine's 15. In the major band specifically: Ranitidine has 3 (also Theophylline, Valproate); Risperidone has 6 (also Amitriptyline, Carbamazepine, Lithium, Erythromycin).
What mechanism field is on file for Ranitidine and Risperidone?
Ranitidine causes a small increase in risperidone levels, but it is not enough to change how the drug works or its safety.
Risperidone carries more major-labeled pairs than Ranitidine
SPL source-record counts only. This page's band is major · classes on file: Ranitidine (H2 Receptor Antagonist); Risperidone (Atypical Antipsychotic).
Risperidone has 6 major-labeled pairs vs Ranitidine's 3.
3 major · 1 moderate · 11 minor · 15 total
- Other major peers for Ranitidine
- Theophylline
- Valproate
6 major · 5 moderate · 9 minor · 20 total
- Other major peers for Risperidone
- Amitriptyline
- Carbamazepine
- Lithium
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.