Clonazepam and Diazepam Interaction
Drug interaction information between Clonazepam and Diazepam.
Clonazepam and Diazepam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clonazepam and Diazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs are both sedatives that slow down your brain and body. Taking them together can make you dangerously sleepy or cause trouble breathing.
FDA Label Information
Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Lamotrigine minor
- Fluconazole minor
Diazepam Also Interacts With
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Diazepam?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diazepam has 26 labeled pairs on file vs Clonazepam's 14. In the moderate band specifically: Clonazepam has 1; Diazepam has 4 (also Fluoxetine, Mirtazapine, Raloxifene).
What mechanism field is on file for Clonazepam and Diazepam?
These drugs are both sedatives that slow down your brain and body. Taking them together can make you dangerously sleepy or cause trouble breathing.
Clonazepam carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is moderate · classes on file: Clonazepam (Benzodiazepine); Diazepam (Benzodiazepine).
Clonazepam has 3 major-labeled pairs vs Diazepam's 0. This page itself is in the moderate band, not the major band.
3 major · 1 moderate · 10 minor · 14 total
Clonazepam has no other moderate-band peer in this dataset besides Diazepam.
0 major · 4 moderate · 22 minor · 26 total
- Other moderate peers for Diazepam
- Fluoxetine
- Mirtazapine
- Raloxifene
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.