Ranitidine and Valproate Interaction
Drug interaction information between Ranitidine and Valproate.
Ranitidine and Valproate have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ranitidine and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine does not change how the body processes or removes valproate from your system. There is no known interaction between these two drugs based on the provided information.
FDA Label Information
Cimetidine and Ranitidine Cimetidine and ranitidine do not affect the clearance of valproate.
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Midazolam moderate
- Clonazepam minor
- Darunavir minor
Valproate Also Interacts With
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Ranitidine + Valproate?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Ranitidine's 15. In the major band specifically: Ranitidine has 3 (also Risperidone, Theophylline); Valproate has 2 (also Cimetidine).
What mechanism field is on file for Ranitidine and Valproate?
Ranitidine does not change how the body processes or removes valproate from your system. There is no known interaction between these two drugs based on the provided information.
Ranitidine carries more major-labeled pairs than Valproate
SPL source-record counts only. This page's band is major · classes on file: Ranitidine (H2 Receptor Antagonist); Valproate (Anticonvulsant / Mood Stabilizer).
Ranitidine has 3 major-labeled pairs vs Valproate's 2.
3 major · 1 moderate · 11 minor · 15 total
- Other major peers for Ranitidine
- Risperidone
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.