Ranitidine and Ibandronate Interaction
Drug interaction information between Ranitidine and Ibandronate.
Ranitidine and Ibandronate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranitidine and Ibandronate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine increases the amount of ibandronate that is absorbed into your body.
FDA Label Information
7.3 H2 Blockers In healthy volunteers, co-administration with ranitidine resulted in a 20% increased bioavailability of ibandronate, which was not considered to be clinically relevant (see CLINICAL PHARMACOLOGY [12.3] ) . 7.3 H2 Blockers In healthy volunteers, co-administration with ranitidine resulted in a 20% increased bioavailability of ibandronate, which was not considered to be clinically relevant (see CLINICAL PHARMACOLOGY [12.3] ) .
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Clonazepam minor
Frequently Asked Questions
What SPL severity band is on file for Ranitidine + Ibandronate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranitidine has 15 labeled pairs on file vs Ibandronate's 2. In the minor band specifically: Ranitidine has 11 (also Clonazepam, Darunavir, Diltiazem, Eprosartan); Ibandronate has 1.
What mechanism field is on file for Ranitidine and Ibandronate?
Ranitidine increases the amount of ibandronate that is absorbed into your body.
Ranitidine carries more major-labeled pairs than Ibandronate
SPL source-record counts only. This page's band is minor · classes on file: Ranitidine (H2 Receptor Antagonist); Ibandronate (Bisphosphonate).
Ranitidine has 3 major-labeled pairs vs Ibandronate's 1. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 11 minor · 15 total
- Other minor peers for Ranitidine
- Clonazepam
- Darunavir
- Diltiazem
- Eprosartan
1 major · 0 moderate · 1 minor · 2 total
Ibandronate has no other minor-band peer in this dataset besides Ranitidine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.