Clonazepam and Fluconazole Interaction
Drug interaction information between Clonazepam and Fluconazole.
Clonazepam and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonazepam and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole blocks the enzymes that break down clonazepam. This can cause clonazepam to build up in your body and increase its effects.
What To Do
Use this combination carefully. Your doctor should monitor you for increased side effects like extreme sleepiness.
FDA Label Information
Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents (e.g., fluconazole), should be used cautiously in patients receiving clonazepam because they may impair the metabolism of clonazepam leading to exaggerated concentrations and effects.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Clonazepam and Fluconazole together?
This is a minor interaction. Use this combination carefully. Your doctor should monitor you for increased side effects like extreme sleepiness.
How serious is the interaction between Clonazepam and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Clonazepam and Fluconazole interact?
Fluconazole blocks the enzymes that break down clonazepam. This can cause clonazepam to build up in your body and increase its effects.
Understanding the Clonazepam and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Clonazepam belongs to the Benzodiazepine class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole blocks the enzymes that break down clonazepam. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clonazepam has 14 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use this combination carefully. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clonazepam or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.