Clonazepam and Fluconazole Interaction
Drug interaction information between Clonazepam and Fluconazole.
Clonazepam and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonazepam and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzymes that break down clonazepam. This can cause clonazepam to build up in your body and increase its effects.
FDA Label Information
Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents (e.g., fluconazole), should be used cautiously in patients receiving clonazepam because they may impair the metabolism of clonazepam leading to exaggerated concentrations and effects.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Clonazepam's 14. In the minor band specifically: Clonazepam has 10 (also Lamotrigine, Carbamazepine, Ranitidine, Phenytoin); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Clonazepam and Fluconazole?
Fluconazole blocks the enzymes that break down clonazepam. This can cause clonazepam to build up in your body and increase its effects.
Fluconazole's labeled portfolio outnumbers Clonazepam
SPL source-record counts only. This page's band is minor · classes on file: Clonazepam (Benzodiazepine); Fluconazole (Azole Antifungal).
3 major · 1 moderate · 10 minor · 14 total
- Other minor peers for Clonazepam
- Lamotrigine
- Carbamazepine
- Ranitidine
- Phenytoin
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.