Clonazepam and Sertraline Interaction
Drug interaction information between Clonazepam and Sertraline.
Clonazepam and Sertraline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Clonazepam and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sertraline does not interfere with how your body breaks down or uses clonazepam.
FDA Label Information
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Clonazepam Also Interacts With
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
- Fluconazole minor
Sertraline Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Sertraline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Clonazepam's 14. In the major band specifically: Clonazepam has 3 (also Fluoxetine, Felbamate); Sertraline has 1.
What mechanism field is on file for Clonazepam and Sertraline?
Sertraline does not interfere with how your body breaks down or uses clonazepam.
Clonazepam carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is major · classes on file: Clonazepam (Benzodiazepine); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Clonazepam has 3 major-labeled pairs vs Sertraline's 1.
3 major · 1 moderate · 10 minor · 14 total
- Other major peers for Clonazepam
- Fluoxetine
- Felbamate
1 major · 2 moderate · 31 minor · 34 total
Sertraline has no other major-band peer in this dataset besides Clonazepam.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.