Clonazepam and Lamotrigine Interaction
Drug interaction information between Clonazepam and Lamotrigine.
Clonazepam and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonazepam and Lamotrigine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Lamotrigine speeds up the process of clearing clonazepam from your body. This results in lower levels of clonazepam in your bloodstream.
What To Do
Your doctor may need to adjust your clonazepam dose to ensure the medicine stays effective.
FDA Label Information
Cytochrome P450 inducers, such as phenytoin, carbamazepine, lamotrigine, and phenobarbital induce clonazepam metabolism, causing an approximately 38% decrease in plasma clonazepam levels.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Fluconazole minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
Can I take Clonazepam and Lamotrigine together?
This is a minor interaction. Your doctor may need to adjust your clonazepam dose to ensure the medicine stays effective.
How serious is the interaction between Clonazepam and Lamotrigine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Clonazepam and Lamotrigine interact?
Lamotrigine speeds up the process of clearing clonazepam from your body. This results in lower levels of clonazepam in your bloodstream.
Understanding the Clonazepam and Lamotrigine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Clonazepam belongs to the Benzodiazepine class and Lamotrigine belongs to the Anticonvulsant class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Lamotrigine speeds up the process of clearing clonazepam from your body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clonazepam has 14 total documented interactions on file in this dataset, and Lamotrigine has 24. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your clonazepam dose to ensure the medicine stays effective. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clonazepam or Lamotrigine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.