Clonazepam and Lamotrigine Interaction
Drug interaction information between Clonazepam and Lamotrigine.
Clonazepam and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonazepam and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lamotrigine speeds up the process of clearing clonazepam from your body. This results in lower levels of clonazepam in your bloodstream.
FDA Label Information
Cytochrome P450 inducers, such as phenytoin, carbamazepine, lamotrigine, and phenobarbital induce clonazepam metabolism, causing an approximately 38% decrease in plasma clonazepam levels.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Fluconazole minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Clonazepam's 14. In the minor band specifically: Clonazepam has 10 (also Fluconazole, Carbamazepine, Ranitidine, Phenytoin); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Clonazepam and Lamotrigine?
Lamotrigine speeds up the process of clearing clonazepam from your body. This results in lower levels of clonazepam in your bloodstream.
Clonazepam carries more major-labeled pairs than Lamotrigine
SPL source-record counts only. This page's band is minor · classes on file: Clonazepam (Benzodiazepine); Lamotrigine (Anticonvulsant).
Clonazepam has 3 major-labeled pairs vs Lamotrigine's 0. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 10 minor · 14 total
- Other minor peers for Clonazepam
- Fluconazole
- Carbamazepine
- Ranitidine
- Phenytoin
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.