Ranitidine and Darunavir Interaction
Drug interaction information between Ranitidine and Darunavir.
Ranitidine and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranitidine and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not interfere with each other's levels or how they work in the body.
FDA Label Information
7.4 Drugs without Clinically Significant Interactions with Darunavir No dosage adjustments are recommended when darunavir/ritonavir is co-administered with the following medications: atazanavir, dolutegravir, efavirenz, etravirine, nevirapine, nucleoside reverse transcriptase inhibitors (abacavir, emtricitabine, emtricitabine/tenofovir alafenamide, lamivudine, stavudine, tenofovir disoproxil fumarate, zidovudine), pitavastatin, raltegravir, ranitidine or rilpivirine.
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Clonazepam minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Ranitidine + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Ranitidine's 15. In the minor band specifically: Ranitidine has 11 (also Clonazepam, Diltiazem, Eprosartan, Ibandronate); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Ranitidine and Darunavir?
These drugs do not interfere with each other's levels or how they work in the body.
Darunavir carries more major-labeled pairs than Ranitidine
SPL source-record counts only. This page's band is minor · classes on file: Ranitidine (H2 Receptor Antagonist); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Ranitidine's 3. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 11 minor · 15 total
- Other minor peers for Ranitidine
- Clonazepam
- Diltiazem
- Eprosartan
- Ibandronate
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.