Ranitidine and Darunavir Interaction
Drug interaction information between Ranitidine and Darunavir.
Ranitidine and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ranitidine and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs do not interfere with each other's levels or how they work in the body.
What To Do
No dose changes are needed, and you can safely take these medicines together.
FDA Label Information
7.4 Drugs without Clinically Significant Interactions with Darunavir No dosage adjustments are recommended when darunavir/ritonavir is co-administered with the following medications: atazanavir, dolutegravir, efavirenz, etravirine, nevirapine, nucleoside reverse transcriptase inhibitors (abacavir, emtricitabine, emtricitabine/tenofovir alafenamide, lamivudine, stavudine, tenofovir disoproxil fumarate, zidovudine), pitavastatin, raltegravir, ranitidine or rilpivirine.
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Clonazepam minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Ranitidine and Darunavir together?
This is a minor interaction. No dose changes are needed, and you can safely take these medicines together.
How serious is the interaction between Ranitidine and Darunavir?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Ranitidine and Darunavir interact?
These drugs do not interfere with each other's levels or how they work in the body.
Understanding the Ranitidine and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Ranitidine belongs to the H2 Receptor Antagonist class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs do not interfere with each other's levels or how they work in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ranitidine has 15 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose changes are needed, and you can safely take these medicines together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ranitidine or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.